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William C. Koller, MD, PhD; Frank Rubino, MD; Sudha Gupta, MD

Arch Neurol. 1987;44(9):905-906.

Abstract
• Progabide, a -aminobutyric acid agonist, was given to ten patients with essential tremor in a double-blind, placebo-controlled crossover study. The effect of progabide did not differ from that of placebo. Alterations in -aminobutyric acid neurotransmission do not appear to be involved in the pathogenesis of essential tremor.

Author Affiliations
From the Department of Neurology, Loyola University School of Medicine, Maywood, Ill, and Hines (Ill) Veterans Administration Hospital.

Footnotes
Accepted for publication May 14, 1987.

Reprint requests to Neurology Service, Hines Veterans Administration Hospital, Hines, IL 60141 (Dr Koller).

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