Pharmacologic probe with progabide of GABA mechanisms in essential tremor
W. C. Koller, F. Rubino and S. Gupta
Progabide, a gamma-aminobutyric acid agonist, was given to ten patients
with essential tremor in a double-blind, placebo-controlled crossover
study. The effect of progabide did not differ from that of placebo.
Alterations in gamma-aminobutyric acid neurotransmission do not appear to
be involved in the pathogenesis of essential tremor.
