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Lupus Anticoagulants and Anticardiolipin Antibodies

Steven R. Levine, MD; K. M. A. Welch, MD

Arch Neurol. 1987;44(8):876-883.

Abstract
• Lupus anticoagulants and anticardiolipin antibodies are antiphospholipid immunoglobulins, predominantly of the IgG, IgM, or mixed class. Recently, these antiphospholipid autoantibodies have been associated with neurologic conditions including focal cerebral and ocular ischemia, the myelopathy of lupoid sclerosis and Degos' disease, Guillain-Barré syndrome, migraine, chorea, and seizures. We review the neurologic manifestations associated with this group of antibodies. Recognition of these conditions may lead to further insights into pathogenesis and therapy.

Author Affiliations
From the Center for Cerebrovascular Disease Research and the Department of Neurology, Henry Ford Hospital, Detroit. Dr Levine is currently a research fellow of the American Heart Association of Michigan, Lathrup Village.

Footnotes
Accepted for publication Feb 23, 1987.

Reprint requests to Department of Neurology, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202 (Dr Levine).

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