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Ronald E. Kramer, MD; Dudley S. Dinner, MD; William E. Braun, MD; Andrea A. Zachary, PhD; Gary A. Teresi

Arch Neurol. 1987;44(8):853-855.

Abstract
• Tissue typing was performed on 14 narcoleptics as defined by both strict sleep laboratory and clinical criteria. Six of these patients were blacks from North America, a race underrepresented in previous studies. All patients were HLA-DR2-antigen positive and had the same HLA-DR2 subtype. Clinical severity of disease was not correlated with HLA-DR2 heterozygosity or (putative) homozygosity. This study confirms that the extremely high association between HLA-DR2 and narcolepsy holds across comparisons of the three races studied to date when both clinical and sleep laboratory data are used. The presence or absence of HLA-DR2 in patients presenting with hyper-somnolence may help support or exclude, respectively, a diagnosis of idiopathic narcolepsy.

Author Affiliations
From the Departments of Neurology (Drs Kramer and Dinner) and Immunopathology (Drs Braun and Zachary, and Mr Teresi), Cleveland Clinic Foundation.

Footnotes
Accepted for publication March 30, 1987.

Reprint requests to Department of Neurology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44106 (Dr Kramer).

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