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Anticoagulation

Patrick D. Lyden, MD; Justin A. Zivin, MD, PhD; Mark Soll, MD; Matthew Sitzer, MD; John F. Rothrock, MD; John Alksne, MD

Arch Neurol. 1987;44(8):848-850.

Abstract
• Embolic stroke was induced in rabbits using autologous blood clot. One hour after stroke, animals received heparin anticoagulation (AC) for five hours (acute AC) or five days (chronic AC). Animals received excessive AC (partial thromboplastin time >3.0 times control), adequate AC (partial thromboplastin time, 1.2 to 2.5 times control), or saline. After the animals were killed, the brains were examined for macroscopic evidence of intracerebral hemorrhage. There was no significant increase over control in the incidence or severity of hemorrhage in any of the four treatment groups. The data suggest that heparin AC does not promote intracerebral hemorrhage after experimental embolic stroke.

Author Affiliations
From the Department of Neurology, Veterans Administration Medical Center (Drs Lyden and Zivin) and the Department of Neurosciences and Neurosurgery, University of California (Drs Lyden, Zivin, Soll, Sitzer, Rothrock, and Alksne), San Diego.

Footnotes
Accepted for publication April 16, 1987.

Reprint requests to Neurology Service (127), Veterans Administration Medical Center, 3350 La Jolla Village Dr, San Diego, CA 92161 (Dr Lyden).

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