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Experimental Neuropathology of Chronic Demyelination Induced by a JHM Virus Variant (DS)
Stephanie S. Erlich, MD;
John O. Fleming, MD;
Stephen A. Stohlman, PhD;
Leslie P. Weiner, MD
Arch Neurol. 1987;44(8):839-842.
Abstract
• A small plaque variant of JHM virus has a markedly reduced ability to kill mice following intracerebral inoculation. Spinal cords of mice surviving 13 to 16 months following acute infection with this variant were examined ultrastructurally. Multiple subpial areas of demyelination in the anterior and lateral white matter were found in five of 13 mice. The lesions had more gliosis, fewer oligodendrocytes, and less remyelination than has been described following other infections with JHM virus. No conclusive evidence of active demyelination or viral-like particles was found. The pathogenesis of the lesions observed may be due to a persistent, attenuated infection of oligodendrocytes or to immunologic processes. These lesions were similar to chronic multiple sclerosis plaques. Therefore, this variant should prove to be a useful tool for studying the long-term effects of viral-induced demyelinating diseases.
Author Affiliations
From the Departments of Neurological Surgery (Dr Erlich), Neurology (Drs Fleming, Stohlman, and Weiner), and Microbiology (Drs Stohlman and Weiner), University of Southern California School of Medicine, Los Angeles.
Footnotes
Accepted for publication March 19, 1987.
Reprint requests to University of Southern California School of Medicine, 2025 Zonal Ave, McKibben 142, Los Angeles, CA 90033 (Dr Fleming).
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