Prednisone treatment in Duchenne muscular dystrophy. Long-term benefit
S. DeSilva, D. B. Drachman, D. Mellits and R. W. Kuncl
We report the long-term results of a therapeutic trial of prednisone in the
treatment of Duchenne muscular dystrophy, comparing the age at which 16
treated patients and 38 controls lost the ability to ambulate. Survival
curve analysis and group mean comparisons indicate that ambulation was
significantly prolonged, by approximately two years, in the
prednisone-treated group compared with the control group. The results of
this study indicate that prednisone therapy has a long-term beneficial
effect in the treatment of Duchenne muscular dystrophy, in addition to the
short-term palliation we previously reported. Further studies are needed to
establish optimal treatment schedules using prednisone and to develop
improved therapeutic agents.
Orthopedic outcomes of long-term daily corticosteroid treatment in Duchenne muscular dystrophy
King et al.
Neurology 2007;68:1607-1613.
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The glucocorticoid receptor N363S polymorphism and steroid response in Duchenne dystrophy
Bonifati et al.
J. Neurol. Neurosurg. Psychiatry 2006;77:1177-1179.
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Steroid Treatment for Cardiac Function in Duchenne Muscular Dystrophy
Danford
AAP Grand Rounds 2006;15:58-59.
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The Muscular Dystrophies: From Genes to Therapies
Lovering et al.
ptjournal 2005;85:1372-1388.
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Molecular, cellular, and pharmacological therapies for Duchenne/Becker muscular dystrophies
Chakkalakal et al.
FASEB J. 2005;19:880-891.
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Practice Parameter: Corticosteroid treatment of Duchenne dystrophy: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society
Moxley et al.
Neurology 2005;64:13-20.
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Respiratory Care of the Patient with Duchenne Muscular Dystrophy: ATS Consensus Statement
Am. J. Respir. Crit. Care Med. 2004;170:456-465.
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Vertebral Fractures in Boys with Duchenne Muscular Dystrophy
Bothwell et al.
CLIN PEDIATR 2003;42:353-356.
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Corticosteroids in Duchenne Muscular Dystrophy: A Reappraisal
Wong and Christopher
J Child Neurol 2002;17:183-190.
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Prednisone Therapy in Becker's Muscular Dystrophy
Johnsen and Clinic
J Child Neurol 2001;16:870-871.
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