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William E. Rosenfeld, MD; Ilo E. Leppik, MD; John R. Gates, MD; Ruy E. Mireles, MD

Arch Neurol. 1987;44(7):709-710.

Abstract
• Of 35 patients who had generalized tonic-clonic seizures during antiepileptic drug therapy withdrawal, "loading" with valproic acid was effective in limiting these seizures in 32 patients. A loading dose of approximately 12.5 mg/kg was used. This dose resulted in valproic acid levels between 284 and 458 µmol/L (41 and 66 mg/L) 1.5 hours after "loading" in six of the eight patients in whom serum concentrations were measured.

Author Affiliations
From the Department of Neurology and Comprehensive Epilepsy Program, University of Minnesota, Minneapolis (Drs Rosenfeld, Leppik, Gates, and Mireles), and St Paul Ramsey Medical Center, St Paul, Minn (Dr Leppik).

Footnotes
Accepted for publication March 30, 1987.

Presented at the 16th Epilepsy International Congress, Hamburg, West Germany, Sept 8, 1985.

Reprint requests to the University of Minnesota, Comprehensive Epilepsy Program, 2701 University Ave SE, Suite 106, Minneapolis, MN 55414 (Dr Rosenfeld).

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