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  Vol. 44 No. 6, June 1987 TABLE OF CONTENTS
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Retrovirus-Associated Myelopathies

Gustavo C. Román, MD

Arch Neurol. 1987;44(6):659-663.


Abstract

• Human T-lymphotropic virus type I (HTLV-I), the causative agent of adult Tcell leukemia and non-Hodgkin's lymphoma (ATLL)—or a cross-reacting retrovirus— has been associated with tropical spastic paraparesis in Martinique, Jamaica, Colombia, Trinidad and Tobago, the Seychelles, and probably also in Zaire. The Caribbean basin and sub-Saharan Africa are endemic for ATLL. A similar etiology has been invoked in a chronic spastic myelopathy occurring in areas of high ATLL endemicity in Japan. An HTLV-I viral antigen has been demonstrated in cerebrospinal fluid lymphocytes of a Japanese patient with myelopathy. Human T-lymphotropic virus type I antibodies have occurred in patients in Florida and Japan (areas of HTLV-I endemicity) who were diagnosed as having clinically definite multiple sclerosis (MS), but not in patients with MS in other parts of the world. Human T-lymphotropic virus type I, like some lentiviruses—visna and human immunodeficiency virus, in particular— may be both lymphotropic and neurotropic. Tropical spastic paraparesis, the Japanese myelopathy, and, perhaps, an MS-like neurologic syndrome, may represent clinical variants of the same disease, a retroviral myelopathy.



Author Affiliations

From the Department of Neurology, Texas Tech University Health Sciences Center School of Medicine, Lubbock.


Footnotes

Accepted for publication Jan 9, 1987.

Reprint requests to Department of Neurology, Room 4A124, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430 (Dr Román).



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