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Patricio F. Reyes, MD; Gregory T. Golden, PhD; Pantaleon L. Fagel, MD; Ruggero G. Fariello, MD; Leonard Katz, MD; Erwin Carner, PhD

Arch Neurol. 1987;44(6):644-645.

Abstract
• Histopathologic examination of the prepiriform cortex (PPC) in four documented cases of dementia of the Alzheimer type revealed increased numbers of neurofibrillary tangles and neuritic plaques. These findings indicate that some early- and late-onset cases of Alzheimer's disease may be associated with significant damage to the PPC, a relay center of the mammalian olfactory system that has extensive connections with structures concerned with cognitive and behavioral functions. Involvement of the PPC may be related to the complex neuropsychiatric manifestations observed in this disorder.

Author Affiliations
From the Departments of Neurology (Drs Reyes, Golden, Fagel, Fariello, and Katz) and Psychiatry and Human Behavior (Dr Carner), Jefferson Medical College, Philadelphia; the Department of Neurology and Research, Veterans Administration Medical Center (Drs Reyes, Golden, and Fariello), and the Department of Pathology, Jefferson Medical College and Veterans Administration Medical Center (Dr Reyes), Coatesville, Pa; and the Department of Neurology, Veterans Administration Medical Center, Wilmington, Del (Dr Katz).

Footnotes
Accepted for publication Feb 11, 1987.

Reprint requests to 1025 Walnut St, Suite 511, Philadelphia, PA 19107 (Dr Reyes).

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