Phosphorus magnetic resonance spectroscopy of partially blocked muscle glycolysis. An in vivo study of phosphoglycerate mutase deficiency
Z. Argov, W. J. Bank, B. Boden, Y. I. Ro and B. Chance
In vivo phosphorus magnetic resonance spectroscopy was used to evaluate the
changes in muscle bioenergetics in a patient with a partial glycolytic
block. Phosphoglycerate mutase-deficient muscle showed the following
evidence: Abnormal accumulation of sugar phosphates does occur, even when
6% enzyme activity is present. The elimination of sugar phosphates was
faster than in complete glycolytic blocks. Mild intracellular acidosis
occurred during ischemic exercise. The energy state was slightly low at
rest but not during exercise. Postexercise recovery was mildly slowed.
These findings suggest that phosphorus magnetic resonance spectroscopy can
detect partial defects, as well as full glycolytic blocks, in muscle
metabolism.
