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Phosphorus Magnetic Resonance Spectroscopy of Partially Blocked Muscle GlycolysisAn In Vivo Study of Phosphoglycerate Mutase Deficiency
Zohar Argov, MD;
William J. Bank, MD;
Barry Boden;
Young-Il Ro, MD;
Britton Chance, PhD
Arch Neurol. 1987;44(6):614-617.
Abstract
• In vivo phosphorus magnetic resonance spectroscopy was used to evaluate the changes in muscle bioenergetics in a patient with a partial glycolytic block. Phosphoglycerate mutase-deficient muscle showed the following evidence: (1) Abnormal accumulation of sugar phosphates does occur, even when 6% enzyme activity is present. (2) The elimination of sugar phosphates was faster than in complete glycolytic blocks. (3) Mild intracellular acidosis occurred during ischemic exercise. (4) The energy state was slightly low at rest but not during exercise. (5) Postexercise recovery was mildly slowed. These findings suggest that phosphorus magnetic resonance spectroscopy can detect partial defects, as well as full glycolytic blocks, in muscle metabolism.
Author Affiliations
From the Departments of Biochemistry/Biophysics (Drs Argov and Chance, and Mr Boden), and Neurology (Drs Argov and Bank), University of Pennsylvania, Philadelphia, and the Department of Neurology, Mount Sinai Hospital, Chicago (Dr Ro).
Footnotes
Accepted for publication Feb 11, 1987.
Reprint requests to Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 (Dr Argov).
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