This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Willem van den Burg, PhD; Adriaan H. van Zomeren, PhD; Jan M. Minderhoud, MD; Albert J. A. Prange, MD; Nicole S. A. Meijer, MA

Arch Neurol. 1987;44(5):494-501.

Abstract
• Forty mildly disabled and clinically stable patients with multiple sclerosis (MS), representative of the corresponding population in Northern Holland, with disability Status Scale scores evenly distributed within the 1 to 4 range, were compared with 40 age-, sex-, and education-matched normal controls on a battery of neuropsychological tests. Apart from impairments in perceptual-motor functioning, generally mild deficiencies in intelligence and, specifically, in memory were displayed in the MS group. Attentional processes appeared uncompromised. Increasing fatigue during testing could not account for poor performance. The memory deficits could be attributed to poor initial learning, although there was also evidence suggesting that accelerated forgetting of what had been learned may appear with the progression of MS. Seven patients (17.5%), as compared with none of the controls, were classified by blind clinical judgment of test performance as definitely impaired.

Author Affiliations
From the Division of Neuropsychology (Drs van den Burg and van Zomeren and Ms Meijer) and the Department of Neurology (Drs Minderhoud and Prange), State University of Groningen (the Netherlands).

Footnotes
Accepted for publication Nov 25, 1986.

Reprint requests to the Division of Neuropsychology, Neurological Clinic, University Hospital, Oostersingel 59, 9713 EZ Groningen, the Netherlands (Dr van den Burg).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Identification, causation, alleviation, and prevention of complications (ICAP): An approach to symptom and disability management in multiple sclerosis
Cohen
Neurology 2008;71:S14-S20.
ABSTRACT | FULL TEXT  

Internet-based cognitive testing in multiple sclerosis
Younes et al.
Mult Scler 2007;13:1011-1019.
ABSTRACT  

The Rao's Brief Repeatable Battery and Stroop test: normative values with age, education and gender corrections in an Italian population
Amato et al.
Mult Scler 2006;12:787-793.
ABSTRACT  

Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis
Nocentini et al.
Mult Scler 2006;12:77-87.
ABSTRACT  

Brain atrophy and lesion load as explaining parameters for cognitive impairment in multiple sclerosis
Lazeron et al.
Mult Scler 2005;11:524-531.
ABSTRACT  

The association between cognitive impairment and physical disability in multiple sclerosis
Lynch et al.
Mult Scler 2005;11:469-476.
ABSTRACT  

Magnetic Resonance Spectroscopy of Memory and Frontal Brain Region in Early Multiple Sclerosis
Staffen et al.
J. Neuropsychiatry Clin. Neurosi. 2005;17:357-363.
ABSTRACT | FULL TEXT  

Cognitive impairment as marker of diffuse brain abnormalities in early relapsing remitting multiple sclerosis
Deloire et al.
J. Neurol. Neurosurg. Psychiatry 2005;76:519-526.
ABSTRACT | FULL TEXT  

An fMRI study of planning-related brain activity in patients with moderately advanced multiple sclerosis
Lazeron et al.
Mult Scler 2004;10:549-555.
ABSTRACT  

The utility of computerized neuropsychological assessment of cognitive dysfunction in patients with relapsing-remitting multiple sclerosis
Wilken et al.
Mult Scler 2003;9:119-127.
ABSTRACT  

Fluency in multiple sclerosis: which measure is best?
Beatty
Mult Scler 2002;8:261-264.
ABSTRACT  

Cognitive function and fMRI in patients with multiple sclerosis: evidence for compensatory cortical activation during an attention task
Staffen et al.
Brain 2002;125:1275-1282.
ABSTRACT | FULL TEXT  

Comparison of two brief neuropsychological batteries in people with multiple sclerosis
Solari et al.
Mult Scler 2002;8:169-176.
ABSTRACT  

Visuoperceptual impairment in multiple sclerosis patients diagnosed with neuropsychological tasks
Vleugels et al.
Mult Scler 2000;6:241-254.
ABSTRACT  

Neuropsychological impairment in multiple sclerosis patients: the role of (juxta)cortical lesion on FLAIR
Lazeron et al.
Mult Scler 2000;6:280-285.
ABSTRACT  

Neuropsychologic Status in Multiple Sclerosis After Treatment With Glatiramer
Weinstein et al.
Arch Neurol 1999;56:319-324.
ABSTRACT | FULL TEXT  

Cognitive Impairment in Early-Onset Multiple Sclerosis: Pattern, Predictors, and Impact on Everyday Life in a 4-Year Follow-up
Amato et al.
Arch Neurol 1995;52:168-172.
ABSTRACT  

What Do We Really Know About Cognitive Dysfunction, Affective Disorders, and Stress in Multiple Sclerosis? A Practitioner's Guide
Fischer et al.
Neurorehabil Neural Repair 1994;8:151-164.
ABSTRACT  

Gist Recall in Multiple Sclerosis
Goldstein et al.
Arch Neurol 1992;49:1060-1064.
ABSTRACT  

Structural equation models in medical research
Bentler and Stein
Stat Methods Med Res 1992;1:159-181.
ABSTRACT  

Screening for Cognitive Impairment in Multiple Sclerosis: An Evaluation of the Mini-Mental State Examination
Beatty and Goodkin
Arch Neurol 1990;47:297-301.
ABSTRACT  

Guidelines for Neuropsychological Research in Multiple Sclerosis
Peyser et al.
Arch Neurol 1990;47:94-97.
ABSTRACT  

Cognitive Disturbances in Patients With Relapsing Remitting Multiple Sclerosis
Beatty et al.
Arch Neurol 1989;46:1113-1119.
ABSTRACT  

A Comparison of Dementia in Alzheimer's Disease and Multiple Sclerosis
Filley et al.
Arch Neurol 1989;46:157-161.
ABSTRACT  

Cognitive Loss in Multiple Sclerosis: Case Reports and Review of the Literature
Franklin et al.
Arch Neurol 1989;46:162-167.
ABSTRACT  

Multiple Memory Deficits in Patients With Multiple Sclerosis: Exploring the Working Memory System
Litvan et al.
Arch Neurol 1988;45:607-610.
ABSTRACT  

Anterograde and Retrograde Amnesia in Patients With Chronic Progressive Multiple Sclerosis
Beatty et al.
Arch Neurol 1988;45:611-619.
ABSTRACT