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A Comparison of Propranolol and Amitriptyline

Dewey K. Ziegler, MD; Aryeh Hurwitz, MD; Ruth S. Hassanein, PhD; H. Altan Kodanaz, PhD; Sheldon H. Preskorn, MD; Judith Mason

Arch Neurol. 1987;44(5):486-489.

Abstract
• The comparative efficacy of propranolol and amitriptyline in the prophylaxis of migraine headache was studied in 30 patients in a double-blind, placebocontrolled, crossover design. Headache response to medication was measured monthly by compilation of headache scores derived from quantitative data recorded by patients in a daily diary; at each visit, Zung and Hamilton tests for depression and the Spielberger state test for anxiety were performed. In the absence of clinical toxicity at monthly visits, the decision to maintain the current dose or raise it was made by a computer, which compared current headache score with that of the previous month. Both drugs were superior to placebo. Neither drug was superior to the other. The effectiveness of neither drug correlated with a decrease in anxiety or depression demonstrated by psychological testing.

Author Affiliations
From the Departments of Neurology (Drs Ziegler and Kodanaz), Medicine (Dr Hurwitz), Biometry (Dr Hassanein and Ms Mason), and Psychiatry (Dr Preskorn), University of Kansas Medical Center, Kansas City.

Footnotes
Accepted for publication Jan 6, 1987.

Reprint requests to Department of Neurology, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66106 (Dr Ziegler).

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