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Cholinesterases in Cerebrospinal FluidA Longitudinal Study in Alzheimer Disease
Roger Elble, MD, PhD;
Ezio Giacobini, MD, PhD;
Gian Franco Scarsella, PhD
Arch Neurol. 1987;44(4):403-407.
Abstract
• We measured acetylcholinesterase (AChE) and butyrylcholinesterase activities in the lumbar cerebrospinal fluid (CSF) of 39 patients with dementia of Alzheimer type and 21 age-matched controls. The mean lumbar CSF AChE activity in our patients did not differ significantly from that of controls. The 7S and 11S molecular forms were also unchanged. When CSF was analyzed at six-month intervals, there was no significant decline in AChE activity over a span of 12 months. Our results and those of previous studies demonstrate that CSF AChE is not a useful diagnostic marker of Alzheimer disease.
Author Affiliations
From the Department of Medicine, Division of Neurology (Dr Elble), and the Department of Pharmacology (Dr Giacobini), Southern Illinois University School of Medicine, Springfield; and the Department of Cell Biology, University of Rome (Dr Scarsella).
Footnotes
Accepted for publication Jan 20, 1987.
Presented in part at the 15th annual meeting of the Society for Neuroscience, Dallas, Oct 22, 1985, and at the 38th annual meeting of the Society of the American Academy of Neurology, New Orleans, May 1, 1986.
Reprint requests to Department of Medicine, Southern Illinois University School of Medicine, 800 N Rutledge, Springfield, IL 62707 (Dr Elble).
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