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Jonathan H. Pincus, MD; Kathryn Barry, MSN, RN

Arch Neurol. 1987;44(3):270-272.

Abstract
• On a nearly zero protein diet, 11 patients with Parkinson's disease with the "on-off" effect demonstrated great sensitivity to levodopa (L-dopa)-carbidopa and reduced fluctuations. Eight patients required a 41% reduction in total L-dopa dosage and discontinuation of all adjuvant therapy to reduce the preponderance of chorea. On a high-protein diet, all patients were immobilized by bradykinesia for most of the day. A low-protein dietary regimen during the daytime offers an important technique for the control of fluctuations in patients with Parkinson's disease who are receiving L-dopa-carbidopa.

Author Affiliations
From the Department of Neurology, Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication Oct 20, 1986.

Read in part before the Scientific Session of the 38th Annual Meeting of the American Academy of Neurology, New Orleans, April 30, 1986.

Reprint requests to Department of Neurology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510 (Dr Pincus).

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