This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Comparison With Alzheimer's Disease and Normal Aging

Munir El-Awar, MD; James T. Becker, PhD; Katherine M. Hammond; Robert D. Nebes, PhD; Francois Boller, MD, PhD

Arch Neurol. 1987;44(2):180-184.

Abstract
• The learning ability of 12 patients with Parkinson's disease (PD) was studied using a verbal paired-associate learning task, and was compared with that of ten patients with Alzheimer's Disease (AD) and 12 controls (NC). Overall, the PD patients performed significantly better than the AD patients but significantly worse than the NC subjects. Their performance was not related to their overall level of cognitive functioning as measured by the Mattis' Dementia Rating Scale, but was unequally distributed suggesting that the PD population actually consisted of more than one subgroup. A low error group performed like controls, while a high error group had a learning impairment comparable to that of AD patients. It is concluded that PD patients may have three patterns of neuropsychologic performance: some are unimpaired, some have "focal" abnormalities, and some have a generalized impairment of cognitive function.

Author Affiliations
From the Departments of Neurology (Drs ElAwar, Becker, and Boller) and Psychiatry (Ms Hammond, Drs Becker, Nebes, and Boller), University of Pittsburgh School of Medicine.

Footnotes
Accepted for publication Sept 16, 1986.

Presented in part at the Annual Meeting of the Society for Neuroscience, Dallas, October 1985.

Reprint requests to Alzheimer's Research Program, 618 Eye and Ear Hospital, 230 Lothrop St. Pittsburgh, PA 15213 (Dr Becker).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cognitive functioning after subthalamic nucleotomy for refractory Parkinson's disease
McCarter et al.
J. Neurol. Neurosurg. Psychiatry 2000;69:60-66.
ABSTRACT | FULL TEXT  

Cognitive functioning after pallidotomy for refractory Parkinson's disease
Perrine et al.
J. Neurol. Neurosurg. Psychiatry 1998;65:150-154.
ABSTRACT | FULL TEXT  

Are cognitive changes the first symptoms of Huntington's disease? A study of gene carriers
Hahn-Barma et al.
J. Neurol. Neurosurg. Psychiatry 1998;64:172-177.
ABSTRACT | FULL TEXT  

Change in Cognitive Function in Idiopathic Parkinson Disease
Bayles et al.
Arch Neurol 1996;53:1140-1146.
ABSTRACT  

Explicit Memory in Alzheimer's, Huntington's, and Parkinson's Diseases
Pillon et al.
Arch Neurol 1993;50:374-379.
ABSTRACT  

Dementia: A Review Emphasizing Clinicopathologic Correlation and Brain-Behavior Relationships
Chui
Arch Neurol 1989;46:806-814.
ABSTRACT  

Cognitive Disturbances in Parkinson's Disease
Beatty et al.
J Geriatr Psychiatry Neurol 1989;2:22-33.
ABSTRACT  

Anterograde and Retrograde Amnesia in Patients With Chronic Progressive Multiple Sclerosis
Beatty et al.
Arch Neurol 1988;45:611-619.
ABSTRACT  

Neuropsychological Performance in Lateralized Parkinsonism
Spicer et al.
Arch Neurol 1988;45:429-432.
ABSTRACT  

Intellectual Impairment in Parkinson's Disease: Clinical, Pathologic, and Biochemical Correlates
Cummings
J Geriatr Psychiatry Neurol 1988;1:24-36.
ABSTRACT  

Thalamic and Subcortical Gliosis With Dementia
Moossy et al.
Arch Neurol 1987;44:510-513.
ABSTRACT