This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Use of Single Photon Emission Computed Tomography and Iofetamine Hydrochloride I 123

Keith A. Johnson, MD; Stefan T. Mueller, MD; Thomas M. Walshe, MD; Robert J. English, CNMT; B. Leonard Holman, MD

Arch Neurol. 1987;44(2):165-168.

Abstract
• We used single photon emission computed tomography (SPECT) to study 15 patients with Alzheimer's disease and nine controls. lofetamine hydrochloride I 123 uptake data were recorded from the entire brain using a rotating gamma camera. Activity ratios were measured for the frontal, posterior parietal, posterior, medial, and lateral cortical temporal regions and striate cortex and were normalized by the activity in the cerebellum. Abnormalities in iofetamine hydrochloride I 123 activity were similar to the abnormalities in glucose metabolism observed with positron emission tomography. Cortical tracer activity was globally depressed in patients with Alzheimer's disease, with the greatest reduction in the posterior parietal cortex.

Author Affiliations
From the Departments of Medicine (Dr Johnson) and Radiology (Drs Mueller and Holman and Mr English), Brigham and Women's Hospital, Boston; the Department of Neurology (Dr Walshe), Brockton-West Roxbury (Mass) Veterans Administration Medical Center; and Harvard Medical School (Drs Johnson, Mueller, Walshe, and Holman and Mr English), Boston. Dr Johnson is now with Massachusetts General Hospital, Boston.

Footnotes
Accepted for publication Sept 20, 1986.

Reprint requests to Department of Radiology, Division of Nuclear Medicine, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (Dr Holman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
Zhang et al.
Brain 2009;0:awp071v1-awp071.
ABSTRACT | FULL TEXT  

Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI.
Du et al.
Neurology 2006;67:1215-1220.
ABSTRACT | FULL TEXT  

Quantitative SPECT Leads to Improved Performance in Discrimination Tasks Related to Prodromal Alzheimer's Disease
El Fakhri et al.
JNM 2004;45:2026-2031.
ABSTRACT | FULL TEXT  

Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer's Disease
Roher et al.
Arterioscler. Thromb. Vasc. Bio. 2003;23:2055-2062.
ABSTRACT | FULL TEXT  

Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease
Bradley et al.
Brain 2002;125:1772-1781.
ABSTRACT | FULL TEXT  

Cerebral Hypoperfusion Generates Cortical Watershed Microinfarcts in Alzheimer Disease
Suter et al.
Stroke 2002;33:1986-1992.
ABSTRACT | FULL TEXT  

Direct Comparison of Spatially Normalized PET and SPECT Scans in Alzheimer's Disease
Herholz et al.
JNM 2002;43:21-26.
ABSTRACT | FULL TEXT  

SPECT perfusion imaging in the diagnosis of Alzheimer's disease: A clinical-pathologic study
Jagust et al.
Neurology 2001;56:950-956.
ABSTRACT | FULL TEXT  

Attention and executive deficits in Alzheimer's disease: A critical review
Perry and Hodges
Brain 1999;122:383-404.
ABSTRACT | FULL TEXT  

Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism
Lehtovirta et al.
J. Neurol. Neurosurg. Psychiatry 1998;64:742-746.
ABSTRACT | FULL TEXT  

Constraints on the cerebral basis for semantic processing from neuroimaging studies of Alzheimer's disease
Grossman et al.
J. Neurol. Neurosurg. Psychiatry 1997;63:152-158.
ABSTRACT | FULL TEXT  

Temporal Lobe Perfusion on Single Photon Emission Computed Tomography Predicts the Rate of Cognitive Decline in Alzheimer's Disease
Wolfe et al.
Arch Neurol 1995;52:257-262.
ABSTRACT  

Topography of Cross-sectional and Longitudinal Glucose Metabolic Deficits in Alzheimer's Disease: Pathophysiologic Implications
Smith et al.
Arch Neurol 1992;49:1142-1150.
ABSTRACT  

Quantitative Changes in Mesial Temporal Volume, Regional Cerebral Blood Flow, and Cognition in Alzheimer's Disease
Pearlson et al.
Arch Gen Psychiatry 1992;49:402-408.
ABSTRACT  

The Role of Brain Single Photon Emission Computed Tomography in the Diagnosis of Primary Progressive Aphasia
McDaniel et al.
Arch Neurol 1991;48:1257-1260.
ABSTRACT  

Cerebral Blood Flow and Dementia in Parkinson's Disease
Kawabata et al.
J Geriatr Psychiatry Neurol 1991;4:194-203.
ABSTRACT  

The Distribution of Cerebral Muscarinic Acetylcholine Receptors In Vivo in Patients With Dementia: A Controlled Study With 123IQNB and Single Photon Emission Computed Tomography
Weinberger et al.
Arch Neurol 1991;48:169-176.
ABSTRACT  

Iofetamine I 123 Single Photon Emission Computed Tomography Is Accurate in the Diagnosis of Alzheimer's Disease
Johnson et al.
Arch Intern Med 1990;150:752-756.
ABSTRACT  

Brain Amyloid and Alzheimer Disease
Vinters et al.
ANN INTERN MED 1988;109:41-54.
ABSTRACT  

Single Photon Emission Computed Tomography in Alzheimer's Disease: Abnormal Iofetamine I 123 Uptake Reflects Dementia Severity
Johnson et al.
Arch Neurol 1988;45:392-396.
ABSTRACT  

HIPDM-SPECT in Patients With Medically Intractable Complex Partial Seizures: Ictal Study
Lee et al.
Arch Neurol 1988;45:397-402.
ABSTRACT