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Samuel F. Berkovic, MD; George Karpati, MD; Stirling Carpenter, MD; Anthony E. Lang, MD

Arch Neurol. 1987;44(11):1184-1187.

Abstract
• Three unrelated patients, aged 4, 18, and 47 years, had generalized dystonia associated with bilateral striatal hypodensities on computed tomography. Mitochondrial encephalopathy was considered to be the most likely diagnosis, but this could not be proved. These patients confirm previous reports linking acquired generalized dystonia with bilateral putaminal lesions and they highlight the problem in differential diagnosis of this clinicoradiologic syndrome.

Author Affiliations
From the Montreal Neurological Institute and the Department of Neurology and Neurosurgery, McGill University, Montreal (Drs Berkovic, Karpati, and Carpenter), and the Division of Neurology, Toronto Western Hospital (Dr Lang).

Footnotes
Accepted for publication June 29, 1987.

Reprint requests to Montreal Neurological Hospital and Institute, 3801 University St, Montreal, Quebec, Canada H3A 2B4 (Dr Karpati).

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