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Keith A. Johnson, MD; Kenneth R. Davis, MD; Ferdinando S. Buonanno, MD; Thomas J. Brady, MD; T. John Rosen, PhD; John H. Growdon, MD

Arch Neurol. 1987;44(10):1075-1080.

Abstract
• To compare the merits of magnetic resonance imaging (MRI) and roentgen ray computed tomography (CT) in assessing patients with dementia, we examined pairs of MR and CT brain images obtained from 26 patients with Alzheimer's disease (AD), eight patients with vascular or mixed dementia, and two patients with Parkinson's disease plus dementia. Magnetic resonance and CT images were independently rated on a qualitative scale of 0 (normal) to 3 (severely abnormal) in 39 separate brain regions. Ratios of anterolateral and third ventricular linear spans to linear skull spans were measured. Abnormalities in subcortical white matter and in hippocampus, enlargement of basal and sylvian cisterns, and ventriculomegaly were more evident on MR than CT scans, but qualitative ratings in all other brain regions were similar. Linear ventricular span ratios based on MR images did not differ significantly from those measured on CT. White matter abnormalities on MR were high signal foci on T2-weighted images whose pathologic substrate was uncertain; in a single case studied pathologically, no abnormalities were detected in brain regions that contained high signal foci. Dementia severity correlated with periventricular white matter abnormalities on both MR and CT images.

Author Affiliations
From the Departments of Neurology (Drs Johnson and Growdon), Radiology (Drs Davis, Buonanno, and Brady), and Medicine (Dr Brady), Massachusetts General Hospital and Harvard Medical School, Boston, and the Department of Brain and Cognitive Sciences (Dr Rosen), Massachusetts Institute of Technology, Cambridge.

Footnotes
Accepted for publication May 12, 1987.

Reprint requests to Department of Neurology, Nuclear Magnetic Resonance Facility, Baker 2, Massachusetts General Hospital, Fruit St, Boston, MA 02114 (Dr Johnson).

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