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The Influence of Smoking on Observed Associations

T. C. Chen, PhD; A. Leviton, MD; S. Edelstein; J. H. Ellenberg, PhD

Arch Neurol. 1987;44(10):1024-1028.

Abstract
• From among the pregnant women in the Collaborative Perinatal Project of the National Institute of Neurological and Communicative Disorders and Stroke, we identified 508 who had migraine, and 3192 who had no history of migraine, of taking headache medication during the previous 12 months, and of headaches during the pregnancy. Migraineurs smoked more heavily and had a longer smoking history than their headache-free peers. Among migraineurs, smokers were not more likely to consume analgesics than nonsmokers. Regardless of smoking classification, more migraineurs consumed tranquilizers, amphetamines, and sleeping pills than headache-free women. Among smokers only, migraine was associated with heart disease, thrombosis/ phlebitis, asthma, peptic ulcer, and pneumonia. In nonsmokers, migraine was associated with drug sensitivity and other allergies.

Author Affiliations
From the Biometry and Field Studies Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Md (Drs Chen, Edelstein, and Ellenberg), and the Departments of Neurology, Children's Hospital and Harvard Medical School, Boston (Dr Leviton).

Footnotes
Accepted for publication June 8, 1987.

Reprint requests to National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Federal Building, 7550 Wisconsin Ave, Room 720, Bethesda, MD 20892 (Dr Chen).

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