Fetal Methylmercury Poisoning: Relationship Between Concentration in Single Strands of Maternal Hair and Child Effects

doi:10.1001/archneur.1987.00520220023010

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Vol. 44 No. 10, October 1987

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Fetal Methylmercury Poisoning

Relationship Between Concentration in Single Strands of Maternal Hair and Child Effects

David O. Marsh, MD; Thomas W. Clarkson, PhD; Christopher Cox, PhD; Gary J. Myers, MD; Laman Amin-Zaki, MD; Sa'adoun Al-Tikriti, MD

Arch Neurol. 1987;44(10):1017-1022.

Abstract

• Pregnant women consumed bread that was prepared frommethylmercurytreated wheat. Single strands of maternal headhair were analyzed by x-ray fluorescence spectrometry. The indexof fetal exposure was the maximum hair mercury concentrationduring gestation. Effects were measured by the frequency ofpsychomotor retardation, seizures, and neurological signs inthe children. A dose-response relationship was demonstratedfor fetal effects of methylmercury. Analysis of single hairstrands provides a better index of acute or subacute fetal exposurethan analysis of bundles of hair; the duration and degree ofexposure are more accurately defined. A sex difference in responseis discussed.

Author Affiliations

From the Department of Neurology (Dr Marsh), the Environmental Health Sciences Center (Dr Clarkson), and the Division of Biostatistics (Dr Cox), University of Rochester (NY) School of Medicine; University of Alabama School of Medicine, Birmingham (Dr Myers); and the Medical College, University of Baghdad, Iraq (Drs Amin-Zaki and Al-Tikriti).

Footnotes

Accepted for publication June 23, 1987.

Reprint requests to Department of Neurology, University of RochesterSchool of Medicine, Rochester, NY 14642 (Dr Marsh).

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