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A Sequential Study Correlating the Electroencephalogram With Psychometric and Quantitative Pathologic Data

Alex Rae-Grant, MD; Warren Blume, MD; Catherine Lau, BScN; Vladimir C. Hachinski, MD; Michael Fisman, MB; Harold Merskey, DM

Arch Neurol. 1987;44(1):50-54.

Abstract
• As part of a longitudinal cohort study of dementia, 139 patients with Alzheimer's disease (dementia of the Alzheimer type, senile dementia of the Alzheimer type, and mixed type [ischemic score, 4 to 7]) and 148 age-matched control subjects were evaluated for electroencephalographic (EEG) abnormalities and their evolution. Electroencephalograms were significantly different in the two groups; EEGs worsened overall in the two groups during a period of one to four years, but most subjects showed no alteration in their EEGs. Some patients showed improvement in their EEG findings during the follow-up period. A strong correlation between EEG grade and psychometric scores was consistently found over sequential studies. In a subgroup of patients on whom autopsies were performed, morphometric neuron loss correlated significantly with EEG severity.

Author Affiliations
From the Department of Clinical Neurological Sciences, University Hospital (Drs Rae-Grant, Blume, and Hachinski), and the Department of Education and Research, London Psychiatric Hospital (Ms Lau, and Drs Fisman and Merskey), London, Ontario.

Footnotes
Accepted for publication Sept 17, 1986.

Reprint requests to the Department of Clinical Neurological Sciences, University Hospital, 339 Windermere Rd, London, Ontario, Canada N6A 5A5 (Dr Blume).

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