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Domenico Inzitari, MD; Fernando Diaz, MD; Allan Fox, MD; Vladimir C. Hachinski, MD; Allan Steingart, MD; Catherine Lau, BScN; Alan Donald, PhD; John Wade, MD; Hazim Mulic, MD; Harold Merskey, DM

Arch Neurol. 1987;44(1):42-47.

Abstract
• Leuko-araiosis was found in 49 of 140 demented patients compared with 12 out of 110 control subjects. Thirty-one of 95 patients with dementia of the Alzheimer's type had leuko-araiosis. A history of stroke was four times more frequent in patients with leuko-araiosis than in those without leuko-araiosis (17.4% and 4.4%, respectively). It occurred in 25% of controls with leuko-araiosis compared with only 2% of those without leuko-araiosis. Mean systolic blood pressure was associated with leuko-araiosis. No association was found for diastolic blood pressure, myocardial infarction, angina, diabetes, or carotid bruits. On logistic regression analysis, the strong association between dementia and leuko-araiosis was mainly explained by a history of stroke. There are common factors in leuko-araiosis and stroke, but stroke alone does not account for leuko-araiosis.

Author Affiliations
From the Department of Neurology, University of Florence (Italy), Careggi Hospital (Dr Inzitari); the Department of Clinical Neurological Sciences, University Hospital (Drs Diaz, Fox, Hachinski), the Department of Education and Research, London Psychiatric Hospital (Drs Steingart and Merskey and Ms Lau), and the Department of Epidemiology and Biostatistics, University of Western Ontario (Dr Donald), London, Ontario; the Department of Neurology, Charing Cross Hospital, London (Dr Wade); and the Department of Neurology, Clinical Medical Centre, Tuzla, Yugoslavia (Dr Mulic).

Footnotes
Accepted for publication Sept 17, 1986.

Reprint requests to Department of Education and Research, London Psychiatric Hospital, 850 Highbury Ave, PO Box 2532, Terminal A, London, Ontario, Canada N6A 4H1 (Dr Merskey).

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