You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 44 No. 1, January 1987 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis)

A. Steingart, V. C. Hachinski, C. Lau, A. J. Fox, F. Diaz, R. Cape, D. Lee, D. Inzitari and H. Merskey

As part of a prospective clinicopathologic study, a cohort of 105 "normal" elderly volunteers was investigated with computed tomographic scans, psychometric testing (Extended Scale for Dementia [ESD]) and neurologic examination. Computed tomographic scans were evaluated for the presence or absence of white matter lucencies, termed leuko-araiosis. These are defined as patchy or diffuse areas of decreased attenuation involving only white matter and with no change in adjacent ventricles or sulci. The nine controls with leuko-araiosis had lower scores on the ESD than the 96 controls without leuko-araiosis (mean ESD with leuko-araiosis, 227.1 +/- 14; without leuko-araiosis, 237.1 +/- 8), and the difference remains significant even after adjusting for the possible confounding effects of age, sex, education, and infarct detected on computed tomography. Significant differences were also found comparing subjects with leuko-araiosis and those without in respect to abnormal gait, limb power, plantar response, and the rooting and palmomental reflexes. Leuko-araiosis may represent a marker for early dementia. The pathophysiology of this finding remains uncertain. Our results suggest that white matter abnormalities play a role in the development of intellectual impairment in the elderly.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Association of gait and balance disorders with age-related white matter changes: The LADIS Study
Baezner et al.
Neurology 2008;70:935-942.
ABSTRACT | FULL TEXT  

Executive Control Function: A Review of Its Promise and Challenges for Clinical Research. A Report From the Committee on Research of the American Neuropsychiatric Association
Royall et al.
J. Neuropsychiatry Clin. Neurosi. 2002;14:377-405.
ABSTRACT | FULL TEXT  

Quantitative MRI findings and cognitive impairment among community dwelling elderly subjects
Koga et al.
J. Neurol. Neurosurg. Psychiatry 2002;72:737-741.
ABSTRACT | FULL TEXT  

Neuropsychiatric Significance of Subcortical Hyperintensity
Campbell and Coffey
J. Neuropsychiatry Clin. Neurosi. 2001;13:261-288.
FULL TEXT  

Extent of Cerebral White Matter Lesions Is Related to Changes of Circadian Blood Pressure Rhythmicity
Sander et al.
Arch Neurol 2000;57:1302-1307.
ABSTRACT | FULL TEXT  

Impact of White Matter Changes on Clinical Manifestation of Alzheimer's Disease : A Quantitative Study
Hirono et al.
Stroke 2000;31:2182-2188.
ABSTRACT | FULL TEXT  

Silent Lacunar Lesions Detected by Magnetic Resonance Imaging of Children With Brain Tumors: A Late Sequela of Therapy
Fouladi et al.
JCO 2000;18:824-824.
ABSTRACT | FULL TEXT  

Does leukoaraiosis predict morbidity and mortality?
Briley et al.
Neurology 2000;54:90-90.
ABSTRACT | FULL TEXT  

Neuropsychological Functioning and MRI Signal Hyperintensities in Geriatric Depression
Kramer-Ginsberg et al.
Am. J. Psychiatry 1999;156:438-444.
ABSTRACT | FULL TEXT  

Relationship Between Balance and Abnormalities in Cerebral Magnetic Resonance Imaging in Older Adults
Tell et al.
Arch Neurol 1998;55:73-79.
ABSTRACT | FULL TEXT  

Postural Dysregulation in Systolic Blood Pressure Is Associated With Worsened Scoring on Neurobehavioral Function Tests and Leukoaraiosis in the Older Elderly Living in a Community
Matsubayashi et al.
Stroke 1997;28:2169-2173.
ABSTRACT | FULL TEXT  

1H-MRS Differentiates White Matter Hyperintensities in Subcortical Arteriosclerotic Encephalopathy From Those in Normal Elderly
Brooks et al.
Stroke 1997;28:1940-1943.
ABSTRACT | FULL TEXT  

Cigarette Smoking Is Correlated With the Periventricular Hyperintensity Grade on Brain Magnetic Resonance Imaging
Fukuda and Kitani
Stroke 1996;27:645-649.
ABSTRACT | FULL TEXT  

Biologic Markers and Neurochemical Correlates of Agitation and Psychosis in Dementia
Kirby and Lawlor
J Geriatr Psychiatry Neurol 1995;8:S2-S7.
ABSTRACT  

The Significance of Cerebral White Matter Abnormalities 100 Years After Binswanger's Report : A Review
Pantoni and Garcia
Stroke 1995;26:1293-1301.
ABSTRACT | FULL TEXT  

Binswanger's Disease: Some Neuropsychological Considerations
Libon et al.
J Geriatr Psychiatry Neurol 1990;3:31-40.
ABSTRACT  

White Matter Lesions on MRI in the Elderly: What Do They Mean?
J Geriatr Psychiatry Neurol 1990;3:55-56.
 

Binswanger's Disease (Part II): Pathogenesis of Subcortical Arteriosclerotic Encephalopathy and Its Relation to Other Dementing Processes
Peterson and Summergrad
J Geriatr Psychiatry Neurol 1989;2:171-181.
ABSTRACT  

Binswanger's Disease (Part I): The Clinical Recognition of Subcortical Arteriosclerotic Encephalopathy in Elderly Neuropsychiatric Patients
Summergrad and Peterson
J Geriatr Psychiatry Neurol 1989;2:123-133.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1987 American Medical Association. All Rights Reserved.