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The Effect of Puberty on the Course of Epilepsy
Nicholas Diamantopoulos, MD;
Patricia K. Crumrine, MD
Arch Neurol. 1986;43(9):873-876.
Abstract
• It has been stated that puberty adversely affects epilepsy. In this retrospective study, 39 patients (24 girls and 15 boys) with onset of epilepsy before puberty were followed up for seven years extending from prepuberty into puberty. A general trend toward fewer seizures during puberty was observed, but this trend reached statistical significance for only the female patients after menarche. These changes were not related to treatment. We conclude that, in general, puberty does not influence epilepsy. In the postmenarche phase of puberty, however, female patients might experience a better seizure control.
Author Affiliations
From the Department of Neurology, University of Michigan Hospitals, Ann Arbor (Dr Diamantopoulos), and the Departments of Neurology and Pediatrics, University of Pittsburgh (Dr Crumrine).
Footnotes
Accepted for publication May 22, 1986.
Reprint requests to Department of Neurology, Children's Hospital of Pittsburgh, 1 Children's Pl, 3705 Fifth Ave at De Soto Street, Pittsburgh, PA 15213-3417 (Dr Crumrine).
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