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Search for a Dose-Response Relationship

Lawrence I. Golbe, MD; Ronald A. Cody, EdD; Roger C. Duvoisin, MD

Arch Neurol. 1986;43(8):774-778.

Abstract
• We tested the hypothesis that the inverse association of smoking and Parkinson's disease (PD) results from a direct pharmacologic benefit of smoking on PD. We mailed questionnaires to the 32 000 members of the United Parkinson Foundation and searched for evidence of a doseresponse effect between increasing intensity of smoking and decreasing intensity of PD. Of the 6006 respondents, 3693 met our diagnostic criteria. Despite confining the analysis to subgroups where confounding effects would be minimized, we found no significant correlation between any measure of smoking and any measure of PD severity and conclude that smoking is probably not of benefit in preventing, delaying, or ameliorating PD.

Author Affiliations
From the Departments of Neurology (Drs Golbe and Duvoisin) and Environmental and Community Medicine (Dr Cody), University of Medicine and Dentistry of New Jersey—Rutgers Medical School, New Brunswick.

Footnotes
Accepted for publication April 10, 1986.

Read in part before the 37th annual meeting of the American Academy of Neurology, Dallas, May 2, 1985.

Reprint requests to Department of Neurology, UMDNJ-Rutgers Medical School, CN-19, New Brunswick, NJ 08903 (Dr Golbe).

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