Pregnancy and Multiple Sclerosis

doi:10.1001/archneur.1986.00520070075022

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Vol. 43 No. 7, July 1986

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Pregnancy and Multiple Sclerosis

Kathy Birk, MD; Richard Rudick, MD

Arch Neurol. 1986;43(7):719-726.

Abstract

• Retrospective studies strongly suggest that pregnancyis an example of a naturally occurring human condition thatconsistently and predictably affects the course of multiplesclerosis (MS). Pregnancy seems to be associated with clinicalMS stability or improvement, while the postpartum period seemsto be one of high risk for clinical flares of the disease symptoms.Similarly, pregnancy protects animals from developing experimentalallergic encephalomyelitis. Immune system changes in pregnancyand MS are reviewed, as they may be involved in the observedclinical effects of pregnancy on MS. Important questions ofthe patient with MS in the childbearing age group are addressed.

Author Affiliations

From the Departments of Obstetrics and Gynecology (Dr Birk) and Neurology (Dr Rudick), University of Rochester (NY) School of Medicine and Dentistry.

Footnotes

Accepted for publication March 13, 1986.

Reprint requests to Department of Obstetrics and Gynecology,Strong Memorial Hospital, Box 668, 601 Elmwood Ave, Rochester,NY 14642 (Dr Birk).

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