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Robert Beckerman, MD; Jill Meltzer, MAT; Augusto Sola, MD; David Dunn, MD; Michael Wegmann, MS

Arch Neurol. 1986;43(7):698-701.

Abstract
• Brain-stem auditory evoked responses were measured during sleep in four infants with congenital central alveolar hypoventilation syndrome (Ondine's syndrome) and four controls matched for age and sex. Delays in peak latencies p III and interpeak latencies p l-lll were consistently seen in these patients but not in the control children. These abnormalities were reproducible and suggested disruption in the normal auditory pathways at the level of the mid to upper brain stem through which fibers pass close to the area of respiratory control. These abnormalities, both electrophysiologic and metabolic, imply a functional disturbance of brain-stem control of ventilation during sleep in infants and children suffering from Ondine's syndrome.

Author Affiliations
From the Constance Kaufman Center for the Study of Breathing Disorders of Infants and Children, and the Departments of Pediatrics (Drs Beckerman and Sola), Physiology (Dr Beckerman and Mr Wegmann), Otolaryngology (Ms Meltzer), and Neurology (Dr Dunn), Tulane University School of Medicine, New Orleans.

Footnotes
Accepted for publication Dec 19, 1985.

Reprint requests to Department of Pediatrics, 1430 Tulane Ave, New Orleans, LA 70112 (Dr Beckerman).

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