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Helen Creasey, MD; Judith M. Rumsey, PhD; Michael Schwartz, MD; Ranjan Duara, MD; Judith L. Rapoport, MD; Stanley I. Rapoport, MD

Arch Neurol. 1986;43(7):669-672.

Abstract
• Brains of 12 physically healthy men, aged 18 to 39 years, with clear childhood diagnoses of infantile autism, and those of 16 healthy age- and sex-matched normal controls, were examined with computed transverse axial tomography. No significant group differences were seen in volumes of cerebrospinal fluid, white matter, gray matter, the third ventricle, the lateral ventricles, the caudate nuclei, lenticular nuclei, or the thalami, or in the relative symmetry of these structures. These results suggest that the cerebral defect in autism is functional or microscopic, without major gross anatomic correlate.

Author Affiliations
From the Laboratory of Neurosciences, National Institute on Aging (Drs Creasey, Schwartz, Duara, and S. Rapoport), and the Child Psychiatry Branch (Drs Rumsey and J. Rapoport), National Institute of Mental Health, Bethesda, Md.

Footnotes
Accepted for publication Dec 6, 1985.

Reprint requests to Bldg 10, Room 6N-240, Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 2020500 (Dr Rumsey).

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