This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal

Christopher M. Filley, MD; John Kelly; Robert K. Heaton, PhD

Arch Neurol. 1986;43(6):574-576.

Abstract
• Forty-one patients with clinically diagnosed Alzheimer's disease were divided into two groups for comparison of neuropsychologic features in those with early- and late-onset disease. Handedness was also assessed in all patients. Twenty-three patients with onset before age 65 had significantly more language impairment, whereas 18 patients with onset at age 65 or older had more difficulty with visuoconstructional function. Memory was severely impaired in all patients. Only one patient in each group was left-handed, and the same results were obtained when these were excluded. These observations support the notion of left hemisphere vulnerability in early-onset Alzheimer's disease and can be interpreted as demonstrating the clinical variability of the illness rather than the necessity of dividing it into two distinct entities.

Author Affiliations
From the Departments of Neurology (Dr Filley and Mr Kelly) and Psychiatry (Dr Heaton), University of Colorado School of Medicine, Denver.

Footnotes
Accepted for publication Nov 20, 1985.

Reprint requests to UCHSC B-183, Department of Neurology, 4200 E Ninth Ave, Denver, CO 80262 (Dr Filley).

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Usefulness of Cube Copying for Evaluating Treatment of Alzheimer's Disease
Palmqvist et al.
AM J ALZHEIMERS DIS OTHER DEMEN 2008;23:439-446.
ABSTRACT  

Cognitive Differences between Early- and Late-Onset Alzheimer's Disease
Licht et al.
AM J ALZHEIMERS DIS OTHER DEMEN 2007;22:218-222.
ABSTRACT  

Neuropsychological stydy of familial Alzheimer's disease caused by mutation E280A in the presenilin 1 gene
Lasprilla et al.
AM J ALZHEIMERS DIS OTHER DEMEN 2003;18:137-146.
ABSTRACT  

Unilateral spatial neglect in AD: Significance of line bisection performance
Ishiai et al.
Neurology 2000;55:364-370.
ABSTRACT | FULL TEXT  

The Influence of Handedness on the Clinical Presentation and Neuropsychology of Alzheimer Disease
Doody et al.
Arch Neurol 1999;56:1133-1137.
ABSTRACT | FULL TEXT  

Factors Affecting Course and Survival in Alzheimer's Disease: A 9-Year Longitudinal Study
Bracco et al.
Arch Neurol 1994;51:1213-1219.
ABSTRACT  

Posterior Cortical Atrophy: Neuropathologic Correlations
Victoroff et al.
Arch Neurol 1994;51:269-274.
ABSTRACT  

Greater Abnormalities of Brain Cerebrospinal Fluid Volumes in Younger Than in Older Patients With Alzheimer's Disease
Sullivan et al.
Arch Neurol 1993;50:359-373.
ABSTRACT  

Influence of Age on Clinical and Psychometric Assessment of Subjects With Very Mild or Mild Dementia of the Alzheimer Type
Rubin et al.
Arch Neurol 1993;50:380-383.
ABSTRACT  

Age at Onset of Alzheimer's Disease: Relation to Language Dysfunction
Bayles
Arch Neurol 1991;48:155-159.
ABSTRACT  

Alzheimer's Disease: Age at Onset and Single-Photon Emission Computed Tomographic Patterns of Regional Cerebral Blood Flow
Jagust et al.
Arch Neurol 1990;47:628-633.
ABSTRACT  

Longitudinal Cognitive Decline in Patients With Alzheimer's Disease
Rebok et al.
J Geriatr Psychiatry Neurol 1990;3:91-97.
ABSTRACT  

Spatial Disorientation in Alzheimer's Disease
Henderson et al.
Arch Neurol 1989;46:391-394.
ABSTRACT  

Alois Alzheimer on Presenile Dementia
Tonkonogy and Moak
J Geriatr Psychiatry Neurol 1988;1:199-206.
ABSTRACT  

Heterogeneity Among Alzheimer's Disease Patients
J Geriatr Psychiatry Neurol 1988;1:235-236.
 

Neuropsychological Function in Alzheimer's Disease: Pattern of Impairment and Rates of Progression
Becker et al.
Arch Neurol 1988;45:263-268.
ABSTRACT  

Neuropsychological Features of Early and Late-Onset Alzheimer's Disease
Koss and Friedland
Arch Neurol 1987;44:797-797.
ABSTRACT