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A Mesocortical Dopaminergic Defect?

Douglas E. Eggertson, MD; Anders A. F. Sima, MD, PhD

Arch Neurol. 1986;43(5):524-527.

Abstract
• We describe a patient with dementia who at postmortem examination was found to have Lewylike bodies throughout the cerebral cortex associated with typical Lewy bodies in the pigmented brainstem nuclei. Moderate numbers of senile plaques but no neurofibrillary tangles were found in the neopallium or in the limbic areas. A positive correlation was found between the distribution of the cortical Lewylike bodies and the proposed distribution of dopamine terminals in the cerebral cortex. Cell loss in the ventral tegmental area and the basal nucleus of Meynert suggest abnormalities in the dopaminergic and cholinergic innervation of the cerebral cortex. The relative lack of senile changes of Alzheimer type make these two proposed abnormalities a more plausible explanation for the dementia in this patient.

Author Affiliations
From the Section of Neuropathology, Department of Pathology, Health Sciences Centre and University of Manitoba, Winnipeg.

Footnotes
Accepted for publication July 10, 1985.

Reprint requests to Department of Pathology, Health Sciences Centre, 700 William Ave, Winnipeg, Manitoba, Canada R3E 0Z3 (Dr Sima).

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