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A Clinical and Nuclear Magnetic Resonance Imaging Study

Lawrence Jacobs, MD; Peter R. Kinkel, MD; William R. Kinkel, MD

Arch Neurol. 1986;43(5):452-455.

Abstract
• Eight of 16 patients with isolated idiopathic optic neuritis were found to have one to several brain lesions by nuclear magnetic resonance scanning. The brain lesions were predominantly located in the periventricular white matter; their appearances, locations, and extents were similar to those seen in recent nuclear magnetic resonance studies of patients with definite multiple sclerosis. All of these brain lesions were clinically silent and were missed by computerized tomography. Idiopathic optic neuritis may be the only manifestation of a multicentric disease process that is disseminated in the central nervous system in the majority of cases.

Author Affiliations
From the Dent Neurologic Institute, Millard Fillmore Hospital (Drs Jacobs, P. R. Kinkel, and W. R. Kinkel), Buffalo, and the Departments of Neurology (Drs Jacobs and W. R. Kinkel), Physiology (Dr Jacobs), and Anatomy (Dr W. R. Kinkel), State University of New York School of Medicine at Buffalo.

Footnotes
Accepted for publication Nov 18, 1985.

Reprint requests to Dent Neurologic Institute, Millard Fillmore Hospital, 3 Gates Circle, Buffalo, NY 14209 (Dr Jacobs).

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