This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal

Norma Rosas, PhD; Julio Sotelo, MD; Dionisio Nieto, MD

Arch Neurol. 1986;43(4):353-356.

Abstract
• IgM antibodies against cysticercus antigens were measured by enzymelinked immunosorbent assay (ELISA) in 133 serum and 126 cerebrospinal fluid (CSF) samples from patients with active neurocysticercosis (NCC), in 61 serum and 32 CSF samples from patients with inactive NCC, and in 556 serum and 449 CSF samples from patients with other neurological disorders. For diagnosis of active NCC the test showed 50% sensitivity with 70% specificity in serum and 87% sensitivity with 95% specificity in CSF. We concluded that the use of the ELISA with serum is not reliable for diagnosis of NCC and therefore cannot be used routinely for the detection of cases or epidemiological studies. Conversely, ELISA used with CSF is highly dependable for detecting all forms of active NCC. The possible explanations for the discrepancy between serum and CSF results are discussed.

Author Affiliations
From the Research Division, Neuroimmunology Department, Instituto Nacional de Neurologia y Neurocirugia, Mexico City.

Footnotes
Accepted for publication Aug 19, 1985.

Reprint requests to Instituto Nacional de Neurologia, Insurgentes Sur 3877, 14410 Mexico 22, DF (Dr Sotelo).

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Topical Review: Neurocysticercosis in Children
Singhi and Singhi
J Child Neurol 2004;19:482-492.
ABSTRACT  

Characterization of the 8-Kilodalton Antigens of Taenia solium Metacestodes and Evaluation of Their Use in an Enzyme-Linked Immunosorbent Assay for Serodiagnosis
Hancock et al.
J. Clin. Microbiol. 2003;41:2577-2586.
ABSTRACT | FULL TEXT  

Proposed diagnostic criteria for neurocysticercosis
Garg et al.
Neurology 2002;58:1315-1316.
FULL TEXT  

Proposed diagnostic criteria for neurocysticercosis
Del Brutto et al.
Neurology 2001;57:177-183.
ABSTRACT | FULL TEXT  

Serological Diagnosis of Human Cysticercosis by Use of Recombinant Antigens from Taenia solium Cysticerci
Hubert et al.
CVI 1999;6:479-482.
ABSTRACT | FULL TEXT  

Albendazole Therapy for Giant Subarachnoid Cysticerci
Brutto et al.
Arch Neurol 1992;49:535-538.
ABSTRACT  

Lacunar Syndrome due to Neurocysticercosis
Barinagarrementeria and Del Brutto
Arch Neurol 1989;46:415-417.
ABSTRACT  

Short Course of Albendazole Therapy for Neurocysticercosis
Sotelo et al.
Arch Neurol 1988;45:1130-1133.
ABSTRACT  

Neurocysticercosis: Two Hundred Thirty-Eight Cases From a California Hospital
Scharf
Arch Neurol 1988;45:777-780.
ABSTRACT  

Neurocysticercosis
Rangel-Guerra et al.
Arch Neurol 1988;45:492-492.
ABSTRACT  

Albendazole vs Praziquantel for Therapy for Neurocysticercosis: A Controlled Trial
Sotelo et al.
Arch Neurol 1988;45:532-534.
ABSTRACT  

Ataxic Hemiparesis From Cysticercosis
Barinagarementeria et al.
Arch Neurol 1988;45:246-246.
ABSTRACT  

Use of Enzyme-Linked Immunosorbent Assay in the Diagnosis of Cysticercosis
Ramirez and Pradilla
Arch Neurol 1987;44:898-898.
ABSTRACT