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The Influence of Seizure Type on the Efficacy of Plasma Concentrations of Phenytoin, Phenobarbital, and Carbamazepine
Dieter Schmidt, MD;
Ilse Einicke;
Ferdinand Haenel, MD
Arch Neurol. 1986;43(3):263-265.
Abstract
• Plasma concentrations of phenytoin, phenobarbital, or carbamazepine were monitored prospectively during successful single-drug therapy in 78 patients who had various types of epileptic seizures. Mean plasma concentrations necessary for complete control of tonic-clonic seizures alone were as follows: phenytoin, 14µg/mL(n = 28); phenobarbital, 18 µg/mL (n = 10); and carbamazepine, 5.5 µg/mL (n = 2). Epilepsy with simple or complex partial seizures alone or together with tonic-clonic seizures was completely controlled at the following plasma concentrations: phenytoin, 23 µg/mL (n = 25); phenobarbital, 37 µg/mL (n = 5); and carbamazepine, 7 µg/mL (n = 7). Higher plasma concentrations of phenytoin, phenobarbital, and carbamazepine are necessary for control in epilepsy with simple or complex partial seizures compared with epilepsy with tonic-clonic seizures alone. The efficacy of plasma concentrations of phenytoin, phenobarbital, and carbamazepine varies with the type of seizure.
Author Affiliations
From the Grosshadern Clinic, Ludwing-Maximilians University, Department of Neurology, Munich.
Footnotes
Accepted for publication Jan 29, 1985.
Reprint requests to Klinikum Grosshadern, Ludwing-Maximilians-Universität, Department of Neurology, Marchioninistrasse 15, 8000 München 70, West Germany (Dr Schmidt).
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