A controlled neuropsychological comparison of Huntington's disease and multiple sclerosis
E. D. Caine, K. A. Bamford, R. B. Schiffer, I. Shoulson and S. Levy
This study compared the intellectual deficits of patients who had the
earliest stages of Huntington's disease (HD) with those of mildly or
moderately affected patients suffering from multiple sclerosis; both groups
were matched for age, education, and ability to function. Twenty-one HD
patients, 30 multiple sclerosis subjects, and 15 matched controls were
evaluated neuropsychologically; all were free of psychoactive medications.
The two patient groups showed similar overall patterns of impairment,
though the HD group had greater verbal and nonverbal memory deficits. The
HD patients also demonstrated significant dyscalculia and showed
indications of developing problems in language usage and copying. These
results are discussed in light of each disorder's neuropathologic
substrate.
fMRI study of episodic memory in relapsing-remitting MS: correlation with T2 lesion volume.
Bobholz et al.
Neurology 2006;67:1640-1645.
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Profile of cognitive progression in early Huntington's disease
Ho et al.
Neurology 2003;61:1702-1706.
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Fluency in multiple sclerosis: which measure is best?
Beatty
Mult Scler 2002;8:261-264.
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Cortical deficits in multiple sclerosis on the basis of subcortical lesions
Jeffery et al.
Mult Scler 2000;6:50-55.
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A Neuropsychological Comparison of Depressed Suicide Attempters and Nonattempters
King et al.
J. Neuropsychiatry Clin. Neurosi. 2000;12:64-70.
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Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex
Feinstein et al.
Mult Scler 1999;5:69-73.
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Neuropsychologic Status in Multiple Sclerosis After Treatment With Glatiramer
Weinstein et al.
Arch Neurol 1999;56:319-324.
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Access to Semantic Memory in Parkinson's Disease and Multiple Sclerosis
Beatty et al.
J Geriatr Psychiatry Neurol 1989;2:153-162.
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