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William C. Koller, MD, PhD

Arch Neurol. 1986;43(2):126-127.

Abstract
• The relative efficacy of trihexiphenidyl hydrochloride, amantadine hydrochloride, and low-dose carbidopa-levodopa in reducing parkinsonian tremor was investigated using objective techniques. Trihexiphenidyl and carbidopa-levodopa decreased tremor by greater than 50%. Some patients responded to one drug but not to the other. Amantadine decreased tremor less than 25%. Monotherapy with trihexiphenidyl or carbidopa-levodopa should be the initial treatment for the tremor of Parkinson's disease.

Author Affiliations
From the Departments of Neurology, Loyola University School of Medicine, Chicago, and Hines (Ill) Veterans Administration Hospital.

Footnotes
Accepted for publication March 12, 1985.

Reprint requests to Neurology Service (127), Hines Veterans Administration Hospital, Hines, IL 60141 (Dr Koller).

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