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Jun Ochiai, MD; Shozo Tobimatsu, MD; Takuro Kobayashi, MD; Tetsuyuki Kitamoto, MD; Tetsuo Kitaguchi, MD; Hirokazu Furuya, MD; Ikuo Goto, MD; Yoshigoro Kuroiwa, MD

Arch Neurol. 1986;43(12):1294-1295.

Abstract
• A 53-year-old man with nonfamilial prealbumin-type amyloid polyneuropathy had severe motor, sensory, and autonomic polyneuropathy, beginning at age 48 years. These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal. Thus, the diagnosis of FAP was excluded. A possible diagnosis of systemic senile amyloidosis was also considered.

Author Affiliations
From the Departments of Neurology (Drs Ochiai, Tobimatsu, Kobayashi, Kitaguchi, Kuroiwa, and Goto) and Neuropathology (Dr Kitamoto) and the Research Laboratory for Genetic Information (Dr Furuya), Kyushu (Japan) University.

Footnotes
Accepted for publication June 29, 1986.

Reprint requests to the Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, 60 3-1-1 Maidashi, Higashiku, Fukuoka 812, Japan (Dr Kobayashi).

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