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Clinical Correlation in 64 Patients With Multiple Sclerosis

James C. Stevens, MD; Martin R. Farlow, MD; Mary K. Edwards, MD; Pao-lo Yu, PhD

Arch Neurol. 1986;43(11):1145-1148.

Abstract
• Sixty-four patients with possible, probable, or definite multiple sclerosis (McAlpine criteria) were clinically evaluated using the expanded disability status scale (EDSS) and Scripps neurologic rating scale (NRS). All were examined with a 0.15T magnetic resonance scanner using T²- and T¹-weighted images. Correlations between EDSS and NRS scores and severity of disease detected on magnetic resonance imaging were determined. Significant correlations existed between EDSS and NRS with magnetic resonance ratings. Moderate correlations were observed in the motor, cerebellar, and brainstem subgroups of the clinical scales. Significant low correlations existed in the mood/mentation, vision (optic nerves), and bowel/bladder subgroups. Clinical and neuroimaging limitations may account for the lack of higher correlations. Significant correlations suggest the utility of magnetic resonance imaging in monitoring disease progression, and it may prove to be the technique of choice in following up patients with multiple sclero

Author Affiliations
From the Department of Neurology, Indiana University School of Medicine, Indianapolis.

Footnotes
Accepted for publication July 28, 1986.

Reprint requests to Department of Neurology, Indiana University School of Medicine, Emerson Hall, Room 125, 545 Barnhill Dr, Indianapolis, IN 46223 (Dr Farlow).

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