This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

James T. Caroscio, MD; Shaul Kochwa, PhD; Henry Sacks, PhD, MD; Sonya Makuku, MT (ASCP); Jeffrey A. Cohen, MD; Melvin D. Yahr, MD

Arch Neurol. 1986;43(11):1129-1131.

Abstract
• The value of various parameters of reporting quantitative cerebrospinal fluid (CSF) IgG levels to indicate disease activity in 34 patients with clinically definite multiple sclerosis was examined. IgG alone correlated significantly with increasing degree of disability and increasing number of clinical central nervous system lesions. There was also a trend toward higher mean IgG levels when the course was relapsing and progressive as opposed to progressive or relapsing. For the IgG index, the relationships were the inverse of that noted with IgG alone. IgG-albumin ratio and IgG synthetic rate did not correlate significantly with course, number of CNS lesions, or degree of disability, and there was no statistically significant relationship between any parameter of reporting quantitative CSF IgG and age, duration of diesase, history of recent exacerbation, or area of first involvement in the nervous system. We conclude that although newer methods of reporting CSF IgG elevations in multiple sclerosis are more sensitive and some of them, more specific, in confirming a diagnosis than CSF IgG alone, this parameter remains the best marker of disease activity in individual patients.

Author Affiliations
From the Departments of Neurology (Drs Caroscio, Cohen, and Yahr), Pathology and Medicine (Drs Kochwa and Makuku), and Biomathematical Sciences (Dr Sacks), Mount Sinai School of Medicine, New York.

Footnotes
Accepted for publication Jan 24, 1986.

Deceased.

Reprint requests to Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L. Levy Pl, New York, NY 10029 (Dr Yahr).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cerebrospinal fluid measures of disease activity in patients with multiple sclerosis
Sellebjerg et al.
Mult Scler 1998;4:475-479.
ABSTRACT  

Cerebrospinal Fluid Immunoglobulins and Multiple Sclerosis: Correspondence With Magnetic Resonance Imaging and Visually Evoked Potential Changes
Muller et al.
Arch Neurol 1989;46:367-371.
ABSTRACT