Infantile spasms. Comparative trial of nitrazepam and corticotropin
F. Dreifuss, J. Farwell, G. Holmes, C. Joseph, L. Lockman, J. A. Madsen, C. J. Minarcik Jr, A. D. Rothner and D. A. Shewmon
Fifty-two patients were enrolled in a four-week randomized multicenter
study comparing nitrazepam and corticotropin in the treatment of infantile
spasms. The drugs' efficacy was evaluated in 48 patients, all less than 2
years of age. Both treatments resulted in a statistically significant
reduction in spasm frequency from that at baseline, but the difference
between treatments was not significant. The number of patients who
experienced side effects was similar in the two treatment groups, but the
adverse effects encountered among the patients treated with corticotropin
were qualitatively more severe and required the discontinuation of
treatment in six patients.
Childhood Epilepsy: What Is the Evidence for What We Think and What We Do?
Camfield and Camfield
J Child Neurol 2003;18:272-287.
ABSTRACT
Infantile Spasms and Lennox-Gastaut Syndrome
Trevathan
J Child Neurol 2002;17:2S9-2S22.
ABSTRACT
West's Syndrome
Shields
J Child Neurol 2002;17:S76-S79.
ABSTRACT
Vigabatrin as a First-Choice Drug in the Treatment of West Syndrome
Fejerman et al.
J Child Neurol 2000;15:161-165.
ABSTRACT
ACTH versus vigabatrin therapy in infantile spasms: A retrospective study
Cossette et al.
Neurology 1999;52:1691-1691.
ABSTRACT
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Topical Review: Vigabatrin in the Treatment of Infantile Spasms in Tuberous Sclerosis: Literature Review
Hancock and Osborne
J Child Neurol 1999;14:71-74.
ABSTRACT
Medical Treatment of West Syndrome in Japan
Watanabe
J Child Neurol 1995;10:143-147.
ABSTRACT
The Treatment of Infantile Spasms by Child Neurologists
Bobele and Bodensteiner
J Child Neurol 1994;9:432-435.
ABSTRACT
Topical Review: Putative Neurotransmitter Abnormalities in Infantile Spasms: Cerebrospinal Fluid Neurochemistry and Drug Effects
Pranzatelli
J Child Neurol 1994;9:119-129.
ABSTRACT
