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Pathologic Correlates of Dementia in Parkinson's Disease
Helena C. Chui, MD;
James A. Mortimer, PhD;
Ursula Slager, MD;
Chris Zarow;
William Bondareff, MD, PhD;
David D. Webster, MD
Arch Neurol. 1986;43(10):991-995.
Abstract
• Histopathologic studies of the cerebral cortex, hippocampus, and three subcortical nuclei were performed in four patients with Parkinson's disease whose mental status had been evaluated by neuropsychologic testing. Clinicopathologic correlations suggest that dementia with marked visuospatial disturbance as well as severe aphasia may be associated with severe neuronal loss in subcortical nuclei, without significant numbers of plaques or tangles in the hippocampus and cerebral cortex. Furthermore, memory loss may not be consistently related to neuronal loss in the nucleus basalis of Meynert, particularly in non-Lewy body parkinsonism.
Author Affiliations
From the Departments of Neurology (Dr Chui), Pathology (Dr Slager), Neurobiology (Ms Zarow), and Psychiatry (Dr Bondareff), University of Southern California School of Medicine, Los Angeles; Rancho Los Amigos Hospital (Drs Chui and Slager), Downey, Calif; the Geriatric Research, Education, and Clinical Center (Dr Mortimer), Veterans Administration Medical Center, Minneapolis; and the Department of Neurology (Drs Mortimer and Webster), University of Minnesota School of Medicine, Minneapolis.
Footnotes
Accepted for publication May 19, 1986.
Reprint requests to 12824 Erickson Ave, Downey, CA 90242 (Dr Chui).
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