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Total Cerebral Blindness due to Acute Demyelination

Lyn A. Sedwick, MD; Terence G. Klingele, MD; Ronald M. Burde, MD; Keith H. Fulling, MD; Mokhtar H. Gado, MD

Arch Neurol. 1986;43(1):85-87.

Abstract
• A 51-year-old woman became blind from involvement of both occipital lobes with a confluent lesion demonstrated by computed tomographic scan. Biopsy showed demyelination consistent with Schilder's 1912 variant of diffuse sclerosis. No cytoplasmic inclusions were found on electron microscopy.

Author Affiliations
From the Departments of Ophthalmology (Drs Sedwick, Klingele, and Burde), Neurology and Neurological Surgery (Dr Burde), Pathology (Dr Fulling), and Radiology (Dr Gado), Washington University School of Medicine, St Louis. Dr Sedwick is now in private practice in Orlando, Fla.

Footnotes
Accepted for publication Oct 10, 1984.

Reprint requests to Department of Ophthalmology, Box 8096,660 S Euclid Ave, St Louis, MO 63110 (Dr Burde).

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