Familial association of intracranial aneurysms and multiple congenital anomalies
H. W. ter Berg, J. B. Bijlsma, J. A. Veiga Pires, J. W. Ludwig, C. van der Heiden, C. A. Tulleken and J. Willemse
The familial occurrence of intracranial aneurysms and the possible
relationship with connective tissue disease are discussed. We studied a
large family in which seven members presented with aneurysms. Another
family member presented with a subarachnoidal hemorrhage. Two other family
members each presented with Marfan's syndrome and an unclassified multiple
congenital anomalies syndrome, respectively. The multiplicity of the
aneurysms in four members is in excess of that found in sporadic or
familial cases with intracranial aneurysms. We suggest a common cause, eg,
a connective tissue disorder for both the intracranial aneurysms, the
Marfan's syndrome, and the unclassified syndrome.
