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Hans W. M. ter Berg, MD; Jan B. Bijlsma, MD; Jose A. Pires Veiga, MD; J. Werner Ludwig, MD; Cees van der Heiden, PhD; Cees A. F. Tulleken, MD; Jacobus Willemse, MD

Arch Neurol. 1986;43(1):30-33.

Abstract
• The familial occurrence of intracranial aneurysms and the possible relationship with connective tissue disease are discussed. We studied a large family in which seven members presented with aneurysms. Another family member presented with a subarachnoidal hemorrhage. Two other family members each presented with Marfan's syndrome and an unclassified multiple congenital anomalies syndrome, respectively. The multiplicity of the aneurysms in four members is in excess of that found in sporadic or familial cases with intracranial aneurysms. We suggest a common cause, eg, a connective tissue disorder for both the intracranial aneurysms, the Marfan's syndrome, and the unclassified syndrome.

Author Affiliations
From the Departments of Child Neurology (Drs ter Berg and Willemse) and Neurosurgery (Dr Tulleken), University Hospital, Utrecht, the Netherlands; the Clinical Genetics Center, Utrecht (Dr Bijlsma); the Department of Radiology, Clinic of Amarante, Amarante, Portugal (Dr Viega Pires); University Children's Hospital "Wilhelmina Kinderziekenhuis," Utrecht (Dr Van der Heiden); the Department of Radiology, St Antonius Hospital, Nieuwegein, the Netherlands (Dr Ludwig); and the Department of Neurology, Regional Hospital Almelo, Almelo, the netherlands (Dr ter Berg).

Footnotes
Accepted for publication Aug 19, 1985.

Reprints not available.

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