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Vol. 42 No. 9, September 1985 TABLE OF CONTENTS
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Sarcoidosis and Its Neurological Manifestations

Barney J. Stern, MD; Allan Krumholz, MD; Carol Johns, MD; Penelope Scott, MD; Jack Nissim, MD

Arch Neurol. 1985;42(9):909-917.


Abstract


• Neurosarcoidosls is a disorder that is difficult to diagnose and manage. We assessed its neurological manifestations in 649 patients seen at The Johns Hopkins Hospital, Baltimore, from 1975 through 1980. Neurological problems could be attributed to neurosarcoidosis in 33 patients (5.1%). The presenting manifestation of sarcoidosis was neurological in 16 (48%) of them. Cranial neuropathy was the most frequent problem, and a peripheral facial nerve palsy was the single most common abnormality. Other manifestations were aseptic meningitis, hydrocephalus, parenchymatous disease of the central nervous system, peripheral neuropathy, and myopathy. Three-quarters of the patients were treated with steroids. The outcome was good in 27 (82%) of 33 episodes of neurological dysfunction in 25 patients with a well-documented clinical course. A thorough investigation of patients with suspected neurosarcoidosis is recommended to establish the diagnosis, delineate the extent of disease, and guide therapy.



Author Affiliations


From the Divisions of Neurology (Drs Stern and Krumholz) and Pulmonary Medicine (Drs Scott and Nissim), Sinai Hospital of Baltimore, and the Departments of Neurology (Drs Stern and Krumholz) and Medicine (Drs Johns, Scott, and Nissim), The Johns Hopkins Hospital and University, Baltimore.


Footnotes


Accepted for publication Oct 1, 1984.

Presented in part at the 108th annual meeting of the American Neurological Association, New Orleans, Oct 4, 1983.

Reprint requests to Division of Neurology, Sinai Hospital of Baltimore, Baltimore, MD 21215 (Dr Stern).



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