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70 Autopsy-Confirmed Cases

Guillermo Izquierdo, MD; Jean-Jacques Hauw, MD; Olivier Lyon-Caen, MD; René Marteau, MD; Raymond Escourolle, MD; André Buge; Paul Castaigne, MD; François Lhermitte, MD

Arch Neurol. 1985;42(9):848-850.

Abstract
• We have evaluated the sensitivity of the most recent and most frequently used criteria for the diagnosis of definite multiple sclerosis by the retrospective study of the clinical files of 70 pathologically confirmed cases. For each case, the date of diagnosis was determined separately using different sets of criteria. The delay of diagnosis was then calculated. The diagnosis was made significantly earlier when certain criteria were used. This was more marked in the earlier years of the disease. We also found that cases of multiple sclerosis with progressive courses were diagnosed later than cases with other courses, whatever the criteria used. This was statistically significant only for a single criterion.

Author Affiliations
From the Clinique de Neurologie et de Neuropsychologie (Drs Izquierdo, Lyon-Caen, Marteau, and Lhermitte), Laboratoire de Neuropathologie Charles Foix (Drs Hauw and Escourolle), Clinique de Neurologie (Dr Buge), and Clinique des Maladies du Système Nerveux (Dr Castaigne), La Salpêtrière, Paris.

Footnotes
Accepted for publication Nov 5, 1984.

Deceased.

Reprint requests to Laboratoire de Neuropathologie Charles Foix, La Salpêtrière, 47 Blvd de l'Hôpital, 75651 Paris Cedex 13, France (Dr Hauw).

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