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Diagnosis by Modern Serologic Techniques

James Russell, DO; Marc Fisher, MD; Justin A. Zivin, MD; John Sullivan, MD; David A. Drachman, MD

Arch Neurol. 1985;42(8):789-792.

Abstract
• Three patients had status epilepticus appearing de novo as the presenting manifestation of Epstein-Barr virus (EBV) encephalopathy. Clinical findings of infectious mononucleosis were absent and EBV-specific serologic tests made or confirmed the diagnosis in each case. Epstein-Barr virus should be considered as a potential cause when status epilepticus occurs in the absence of previous seizures or an identified cause of seizures. The diagnosis may be made in some cases only with the use of EBV-specific serologic testing.

Author Affiliations
From the Departments of Neurology (Drs Russell, Fisher, Zivin, and Drachman) and Pediatrics (Dr Sullivan), University of Massachusetts Medical Center, Worcester.

Footnotes
Accepted for publication Aug 15, 1984.

Presented as a poster at the 34th meeting of the American Academy of Neurology, Washington, DC, April 29, 1982.

Reprint requests to Department of Neurology, University of Massachusetts Medical Center, 55 Lake Ave N, Worcester, MA 01605 (Dr Russell).

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