Alternate-day clonazepam treatment of intractable seizures
P. K. Sher
Several investigations have demonstrated a reduction in benzodiazepine
receptor binding after long-term exposure to this class of drugs. Such
receptor alterations may contribute to the decreased efficacy of
benzodiazepines in the management of convulsive disorders. To minimize
receptor alterations, several patients with intractable seizures received
alternate-day clonazepam therapy, resulting in improved seizure control.
The favorable clinical responses suggest that alternative methods of
benzodiazepine administration may circumvent receptor subsensitivity
resulting from prolonged drug treatment.
