This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Clinical Efficacy and Benefit

Bruno A. Wroblewski, MS, Pharm; William H. Garvin, Jr, MD

Arch Neurol. 1985;42(7):699-700.

Abstract
• The clinical anticonvulsant efficacy of once-daily administration of phenobarbital sodium was evaluated in 29 adults with head injuries. All patients were initially well controlled, with therapeutic blood levels of phenobarbital obtained from divided dose regimens, ranging from two to four daily administrations. All therapies were then converted to once-daily administration of the total dose at bedtime. Twenty-six patients (93%) remained with-in normal therapeutic blood levels without any dose change. Phenobarbital can safely, and perhaps should, be administered in a once-a-day regimen, with resultant benefits of probable increased compliance and decreased daytime sedation, if administered at bedtime.

Author Affiliations
From the Greenery (Mr Wroblewski and Dr Garvin) and the Department of Medicine, St Elizabeth's Hospital (Dr Garvin), Brighton, Mass.

Footnotes
Accepted for publication June 12, 1984.

Reprint requests to the Greenery Rehabilitation Center, 99-111 Chestnut Hill Ave, Brighton, MA 02135 (Mr Wroblewski).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?