Intraneuronal accumulation of myeloma proteins
L. F. Borges and N. A. Busis
We studied a patient with multiple myeloma who had immunologically
identified myeloma light chain proteins within neurons projecting beyond
the blood-brain barrier, but not within intrinsic neurons of the spinal
cord, brain stem, and cerebral cortex. There was a possibility that these
myeloma light chain proteins or their immunologically recognizable
fragments were transported intra-axonally by human peripheral nerves.
Myeloma light chain proteins were also identified within cerebellar
Purkinje's neurons. This labeling may have been secondary to transport from
cerebrospinal fluid.