Chronic progressive multiple sclerosis. Relationship between cerebral ventricular size and neuropsychological impairment

S. M. Rao, S. Glatt, T. A. Hammeke, M. P. McQuillen, B. O. Khatri, A. M. Rhodes and S. Pollard

Forty-seven patients with chronic progressive multiple sclerosis were examined to assess the possible relationship between cerebral atrophy (by computed tomography [CT] ) and performance on neuropsychological tests of memory and verbal intelligence. Nineteen patients were found to have mildly dilated ventricles and another nine patients had moderate to severe ventricular enlargement. Performance on memory and intelligence testing was related to the degree of ventriculomegaly. Three linear CT measurements were also recorded. Using this method, the width of the third ventricle proved to be the best indicator of intellectual and memory dysfunction. Measures of cognition and ventricular size did not correlate with length of illness or overall disability as rated by the Kurtzke Disability Status Score.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis
Glanz et al.
Mult Scler 2007;13:1004-1010.
ABSTRACT  

Memory performance in multiple sclerosis patients correlates with central brain atrophy
Hildebrandt et al.
Mult Scler 2006;12:428-436.
ABSTRACT  

Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis
Brass et al.
Mult Scler 2006;12:437-444.
ABSTRACT  

Cognitive impairment as marker of diffuse brain abnormalities in early relapsing remitting multiple sclerosis
Deloire et al.
J. Neurol. Neurosurg. Psychiatry 2005;76:519-526.
ABSTRACT | FULL TEXT  

Neocortical volume decrease in relapsing-remitting MS patients with mild cognitive impairment
Amato et al.
Neurology 2004;63:89-93.
ABSTRACT | FULL TEXT  

Prediction of Neuropsychological Impairment in Multiple Sclerosis: Comparison of Conventional Magnetic Resonance Imaging Measures of Atrophy and Lesion Burden
Benedict et al.
Arch Neurol 2004;61:226-230.
ABSTRACT | FULL TEXT  

Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients
Christodoulou et al.
Neurology 2003;60:1793-1798.
ABSTRACT | FULL TEXT  

Eight-year follow-up study of brain atrophy in patients with MS
Fisher et al.
Neurology 2002;59:1412-1420.
ABSTRACT | FULL TEXT  

Longitudinal Brain Volume Measurement in Multiple Sclerosis: Rate of Brain Atrophy Is Independent of the Disease Subtype
Kalkers et al.
Arch Neurol 2002;59:1572-1576.
ABSTRACT | FULL TEXT  

MRI in the diagnosis and management of multiple sclerosis
Arnold and Matthews
Neurology 2002;58:S23-31.
ABSTRACT | FULL TEXT  

Cognitive Dysfunction in Early-Onset Multiple Sclerosis: A Reappraisal After 10 Years
Amato et al.
Arch Neurol 2001;58:1602-1606.
ABSTRACT | FULL TEXT  

Brain Atrophy in Relapsing-Remitting Multiple Sclerosis: Fractional Volumetric Analysis of Gray Matter and White Matter
Ge et al.
Radiology 2001;220:606-610.
ABSTRACT | FULL TEXT  

Intra-observer, inter-observer and inter-scanner variations in brain MRI volume measurements in multiple sclerosis
Gasperini et al.
Mult Scler 2001;7:27-31.
ABSTRACT  

Enhancing Magnetic Resonance Imaging Lesions and Cerebral Atrophy in Patients With Relapsing Multiple Sclerosis
Leist et al.
Arch Neurol 2001;58:57-60.
ABSTRACT | FULL TEXT  

A Longitudinal Study of Callosal Atrophy and Interhemispheric Dysfunction in Relapsing-Remitting Multiple Sclerosis
Pelletier et al.
Arch Neurol 2001;58:105-111.
ABSTRACT | FULL TEXT  

Relationship between brain atrophy and disability: an 8-year follow-up study of multiple sclerosis patients
Fisher et al.
Mult Scler 2000;6:373-377.
ABSTRACT  

Neuropsychological counseling improves social behavior in cognitively-impaired multiple sclerosis patients
Benedict et al.
Mult Scler 2000;6:391-396.
ABSTRACT  

A longitudinal study of ventricular volume in early relapsing-remitting multiple sclerosis
Luks et al.
Mult Scler 2000;6:332-337.
ABSTRACT  

The Correlation Between Ventricular Diameter Measured by Transcranial Sonography and Clinical Disability and Cognitive Dysfunction in Patients With Multiple Sclerosis
Berg et al.
Arch Neurol 2000;57:1289-1292.
ABSTRACT | FULL TEXT  

Brain Atrophy in Relapsing-Remitting Multiple Sclerosis and Secondary Progressive Multiple Sclerosis: Longitudinal Quantitative Analysis
Ge et al.
Radiology 2000;214:665-670.
ABSTRACT | FULL TEXT  

Progressive cerebral atrophy in MS: A serial study using registered, volumetric MRI
Fox et al.
Neurology 2000;54:807-812.
ABSTRACT | FULL TEXT  

A longitudinal study of brain atrophy in relapsing multiple sclerosis
Simon et al.
Neurology 1999;53:139-139.
ABSTRACT | FULL TEXT  

Infratentorial atrophy on magnetic resonance imaging and disability in multiple sclerosis
Edwards et al.
Brain 1999;122:291-301.
ABSTRACT | FULL TEXT  

Are there any body fluid markers of brain atrophy in multiple sclerosis?
Giovannoni et al.
Mult Scler 1998;4:138-142.
ABSTRACT  

Identification of brain atrophy with MRI in MS
Thompson
Mult Scler 1998;4:257-259.