This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (126)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Livia Candelise, MD; Gianluca Landi, MD; Eduardo Nobile Orazio, MD; Eduardo Boccardi, MD

Arch Neurol. 1985;42(7):661-663.

Abstract
• Prognostic significance of hyperglycemia on short-term survival was evaluated in 72 patients with acute hemispheric stroke. All patients were admitted within 48 hours of onset, and the neurologic deficit was assessed by means of a standardized score. A computed tomogram was taken in all cases on admission. Mortality was higher in hyperglycemic patients with no history of diabetes mellitus (78%) than in diabetic (45%) and in normoglycemic nondiabetic (29%) patients. In nondiabetic patients, the glucose level correlated with the neurologic score and with lesion size on computed tomogram. Reactive hyperglycemia due to a major stress response accounts for the worse prognosis of these patients. This correlation was not found in diabetic patients. Preexisting hyperglycemia, as well as systemic complications, could explain the higher mortality in these patients compared with normoglycemic nondiabetic patients.

Author Affiliations
From the Clinica Neurologica II, Università degli Studi di Milano, Milan, Italy.

Footnotes
Accepted for publication Sept 7, 1984.

Reprint requests to Clinica Neurologica II, Via F. Sforza, 35, 20122 Milano, Italy (Dr Candelise).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Prognostic Value of Capillary Glucose Levels in Acute Stroke: The GLycemia in Acute Stroke (GLIAS) Study
Fuentes et al.
Stroke 2009;40:562-568.
ABSTRACT | FULL TEXT  

Dynamic of Hyperglycemia as a Predictor of Stroke Outcome in the ECASS-II Trial
Yong and Kaste
Stroke 2008;39:2749-2755.
ABSTRACT | FULL TEXT  

Early neurological deterioration in acute ischaemic stroke: predictors, mechanisms and management
Thanvi et al.
Postgrad. Med. J. 2008;84:412-417.
ABSTRACT | FULL TEXT  

Management of Hyperglycemia in Acute Stroke: How, When, and for Whom?
McCormick et al.
Stroke 2008;39:2177-2185.
FULL TEXT  

Hyperglycaemia and mortality
Asadollahi et al.
JRSM 2007;100:503-507.
ABSTRACT | FULL TEXT  

Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.
Adams et al.
Circulation 2007;115:e478-e534.
ABSTRACT | FULL TEXT  

Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
Adams et al.
Stroke 2007;38:1655-1711.
ABSTRACT | FULL TEXT  

Part 9: Stroke
Circulation 2005;112:III-110-III-104.
FULL TEXT  

Admission blood glucose and short term survival in primary intracerebral haemorrhage: a population based study
Fogelholm et al.
J. Neurol. Neurosurg. Psychiatry 2005;76:349-353.
ABSTRACT | FULL TEXT  

Hyperglycemia in the Hospital Setting: The Case for Improved Control Among Non-Diabetics
Conner et al.
The Annals of Pharmacotherapy 2005;39:492-501.
ABSTRACT | FULL TEXT  

Insular Cortical Ischemia Is Independently Associated With Acute Stress Hyperglycemia
Allport et al.
Stroke 2004;35:1886-1891.
ABSTRACT | FULL TEXT  

The Involvement of Glucose Metabolism in the Regulation of Inducible Nitric Oxide Synthase Gene Expression in Glial Cells: Possible Role of Glucose-6-Phosphate Dehydrogenase and CCAAT/Enhancing Binding Protein
Won et al.
J. Neurosci. 2003;23:7470-7478.
ABSTRACT | FULL TEXT  

Guidelines for the Early Management of Patients With Ischemic Stroke: A Scientific Statement From the Stroke Council of the American Stroke Association
Adams et al.
Stroke 2003;34:1056-1083.
FULL TEXT  

Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial
Bruno et al.
Neurology 2002;59:669-674.
ABSTRACT | FULL TEXT  

Hyperglycemia: An Independent Marker of In-Hospital Mortality in Patients with Undiagnosed Diabetes
Umpierrez et al.
J. Clin. Endocrinol. Metab. 2002;87:978-982.
ABSTRACT | FULL TEXT  

Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic Overview
Capes et al.
Stroke 2001;32:2426-2432.
ABSTRACT | FULL TEXT  

Spreading Depression–Induced Gene Expression Is Regulated by Plasma Glucose • Editorial Comment
Koistinaho et al.
Stroke 1999;30:114-119.
ABSTRACT | FULL TEXT  

Effects of Glucose and PaO2 Modulation on Cortical Intracellular Acidosis, NADH Redox State, and Infarction in the Ischemic Penumbra • Editorial Comment
Anderson et al.
Stroke 1999;30:160-170.
ABSTRACT | FULL TEXT  

The Poisoned Patient With Altered Consciousness: Controversies in the Use of a 'Coma Cocktail'
Hoffman and Goldfrank
JAMA 1995;274:562-569.
ABSTRACT  

The Influence of Hyperglycemia on Outcome of Cerebral Infarction
Matchar et al.
ANN INTERN MED 1992;117:449-456.
ABSTRACT